Medication

Stimulant vs. Non-Stimulant ADHD Medications: What's the Difference?

December 16, 20253 min read

ADHD medications can be life-changing, when used as part of a treatment plan. However, understanding the different types of medication will help you make an informed decision. When you’re diagnosed, your GP can prescribe both stimulant and non-stimulant options. Let’s break down the benefits and potential downfalls of each route.

When you have an ADHD diagnosis, it opens the door to treatment options including prescription medication. You may work with your physician to trial different types of treatment, depending on your general health and other factors. The two main options are stimulant and non-stimulant medications. In this guide, we will cover the main differences you can expect.

What is Stimulant Medication for ADHD?

There are many different medications available. In the UK, the most commonly prescribed stimulant medications are Methylphenidate (like Ritalin, Concerta, Medikinet) and Amphetamine-based drugs (like Lisdexamfetamine or Elvanse).

These medications are prescribed to help people manage symptoms such as:

  • Hyperactivity

  • Impulsive behaviour

  • Attention span problems

  • Low moods

Stimulant medication for ADHD works by increasing the levels of chemicals in your brain, such as dopamine and norepinephrine. People often report feeling more alert, having a better attention span, and feeling happier overall. Your doctor will work with you to determine what the right dosage is, and decide whether to use short-acting or long-acting medication.

Side Effects of Stimulant Medication

Side effects are common, especially when you first start taking stimulant medication. While everyone is different, you may find that you experience some of the following:

  • Upset stomach

  • Headaches

  • High blood pressure

  • Loss of appetite (and weight loss)

  • Nervousness

  • Insomnia

When you’re trialing your meditation, it’s important to document any side effects you experience. The more accurate the information you share with them is, the better they will understand what to do next.

What is Non-Stimulant Medication for ADHD?

Non-stimulant medications are used when stimulant medication isn’t right for you. The most common types doctors prescribe in the UK are Atomoxetine (Strattera) and Guanfacine (Intuniv). These work by increasing the brain chemical noradrenaline and inhibiting noradrenaline reuptake. This typically takes longer to affect you than stimulant medication.

Non-stimulant medication can help you manage symptoms including:

  • Hyperactivity

  • Inattention

  • Impulsivity

Non-stimulant medication tends to be either the second or third-line of treatment options that you will be prescribed. This is because it is often less effective than stimulant medication and you have to trial it for longer to see its benefits. However, for some people, non-stimulant medication actually works better.

Side Effects of Non-Stimulant Medication

While the side effects you experience depend on the type of non-stimulant medication you take as well as other factors, there are some common ones to look out for. Here are some of the main issues that people encounter when taking this type of medication:


  • Sleepiness

  • Dry mouth

  • Slow heart rate

  • Low blood pressure

  • Dizziness

  • Irritability

Once again, you will need to work with your doctor to determine whether the non-stimulant medication can work in the long-term. If these side effects are negatively impacting your quality of life, it may not be the right medication for you. Be clear about how the medication affects you.

Making an Informed Decision

Finding the right medication for your treatment plan can be a long and challenging experience. The first step is getting an ADHD assessment and speaking with your GP. You will then be eligible to start the titration process and trial medications to help you to manage your symptoms. Every ADHD person is unique, and finding the right treatment plan demands a unique approach.

Disclaimer: This post is not intended as medical advice. For more information on ADHD medications, reach out to your GP.


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